Smash Run is a mode in the 3DS version: you explore a kind of dungeon, fight enemies from every series and collect power-ups before a final battle. Several Pokémon appear among the enemies, according to Poképédia.
| Pokémon | Move | Effect |
|---|---|---|
| Chandelure | Shadow Ball, Fire Spin | Traps the player in a tornado of flames; immune to fire |
| Koffing | Haze | Makes the player lose some of the collected power-ups |
| Gastly | — | Immune to physical hits; only projectiles can touch it |
| Petilil | Sleep Powder | Puts the player to sleep |
| Cryogonal | Ice Beam | Freezes the player |
